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Alcoholic beverages and preparations containing ethanol or propylene glycol should be avoided during tinidazole therapy and for 3 days afterward because abdominal crampsnauseavomitingheadachesand flushing may occurPsychotic reactions have been reported in alcoholic patients using metronidazole and disulfiram concurrentlyThough no similar reactions have been reported with tinidazoletinidazole should not be given to patients who have taken disulfiram within the last two weeks.

Prescribing Tindamax in the absence of a proven or strongly suspected bacterial infection or a prophylactic indication is unlikely to provide benefit to the patient and increases the risk of the development of drug-resistant bacteria.

The most common adverse reactions in treated patientsincidence2which were not identified in the trichomoniasisgiardiasis and amebiasis studiesare gastrointestinaldecreased appetiteand flatulencerenalurinary tract infectionpainful urinationand urine abnormalityand other reactions including pelvic painvulvo-vaginal discomfortvaginal odormenorrhagiaand upper respiratory tract infectionSee Clinical Studies

Prescribing Tindamax in the absence of a proven or strongly suspected bacterial infection or a prophylactic indication is unlikely to provide benefit to the patient and increases the risk of the development of drug-resistant bacteria.

Metronidazole was shown to decrease the clearance of fluorouracilresulting in an increase in side-effects without an increase in therapeutic benefitsIf the concomitant use of tinidazole and fluorouracil cannot be avoidedthe patient should be monitored for fluorouracil-associated toxicities.

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both metronidazole and tinidazole may interact with other drugs, so it is important to read the instructions and prescription information carefully.